RAD51 genes have different roles in Physcomitrella patens and Arabidopsis thaliana
نویسندگان
چکیده
The eukaryotic RecA homologue RAD51 plays an essential role in homologous recombination and DNA damage repair in yeast. The lethality of rad51 mutants in vertebrates suggests that this gene has acquired additional functions at the interface of recombination and cell-cycle control in some animals. However, viability and unaltered vegetative development in a RAD51 knockout mutant in Arabidopsis thaliana suggests that this additional function is absent in plants. The moss Physcomitrella patens is exceptional in the plant kingdom in its gene targeting efficiency, a process based on homologous recombination. To analyse the recombination apparatus of Physcomitrella and to compare a gene targeting efficient and inefficient organism, we have isolated RAD51 homologues of Physcomitrella.
منابع مشابه
Differential requirements for RAD51 in Physcomitrella patens and Arabidopsis thaliana development and DNA damage repair.
RAD51, the eukaryotic homolog of the bacterial RecA recombinase, plays a central role in homologous recombination (HR) in yeast and animals. Loss of RAD51 function causes lethality in vertebrates but not in other animals or in the flowering plant Arabidopsis thaliana, suggesting that RAD51 is vital for highly developed organisms but not for others. Here, we found that loss of RAD51 function in ...
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